omicsRCD is a multivariate pathway enrichment analysis tool that identifies RCD gene sets over-represented in a list or matrix of genes. It combines multiple omics datasets based on a data fusion method, prioritises genes based on the significance of signals from the omics datasets, and performs pathway enrichment analysis of these prioritised genes. It can find active RCD pathways supported by single or multiple omics datasets, as well as those that are only apparent through data integration and remain undetected in any single dataset alone.